CATH Classification

Domain Context

CATH Clusters

Superfamily Hexapeptide repeat proteins
Functional Family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase

Enzyme Information

1.5.5.2
Proline dehydrogenase.
based on mapping to UniProt P9WP21
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
-!- The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor. -!- In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88. -!- Both activities are carried out by the same enzyme in enterobacteria. -!- Formerly EC 1.5.99.8.
2.3.1.117
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase.
based on mapping to UniProt P9WP21
Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.
-!- Involved in the biosynthesis of lysine in bacteria, cyanobacteria and higher plants. -!- Earlier erroneously called 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase.

UniProtKB Entries (1)

P9WP21
DAPD_MYCTU
Mycobacterium tuberculosis H37Rv
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

PDB Structure

PDB 3FSX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The three-dimensional Structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism.
Schuldt, L., Weyand, S., Kefala, G., Weiss, M.S.
J.Mol.Biol.