CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Methionine aminopeptidase 2

Enzyme Information

3.4.11.18
Methionyl aminopeptidase.
based on mapping to UniProt Q8SR45
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
-!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A.

UniProtKB Entries (1)

Q8SR45
MAP2_ENCCU
Encephalitozoon cuniculi GB-M1
Methionine aminopeptidase 2

PDB Structure

PDB 3FM3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
Alvarado, J.J., Nemkal, A., Sauder, J.M., Russell, M., Akiyoshi, D.E., Shi, W., Almo, S.C., Weiss, L.M.
Mol.Biochem.Parasitol.