CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.35 | Fructose Permease |
|
3.40.35.10 | Phosphotransferase system, sorbose subfamily IIB component |
Domain Context
CATH Clusters
| Superfamily | Phosphotransferase system, sorbose subfamily IIB component |
| Functional Family | PTS system, mannose/fructose/sorbose family, IIB component |
Enzyme Information
| 2.7.1.69 |
Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208.
based on mapping to UniProt Q8XAB8
|
| 2.7.1.191 |
Protein-N(pi)-phosphohistidine--D-mannose phosphotransferase.
based on mapping to UniProt Q8XAB8
[Protein]-N(pi)-phospho-L-histidine + D-mannose(Side 1) = [protein]-L- histidine + D-mannose 6-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.
|
UniProtKB Entries (1)
| Q8XAB8 |
Q8XAB8_ECO57
Escherichia coli O157:H7
Galactosamine-specific PTS system enzyme IIB component
|
PDB Structure
| PDB | 3EYE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of PTS system N-acetylgalactosamine-specific IIB component 1 from Escherichia coli
To be Published
|