CATH Classification

Domain Context

CATH Clusters

Superfamily Leucine Aminopeptidase, subunit E, domain 1
Functional Family Replicase polyprotein 1ab

Enzyme Information

3.4.22.-
Cysteine endopeptidases.
based on mapping to UniProt P0C6Y1
2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P0C6Y1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.4.12
DNA helicase.
based on mapping to UniProt P0C6Y1
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P0C6Y1
3.6.4.13
RNA helicase.
based on mapping to UniProt P0C6Y1
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
3.1.13.-
Exoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P0C6Y1
2.1.1.-
Methyltransferases.
based on mapping to UniProt P0C6Y1

UniProtKB Entries (1)

P0C6Y1
R1AB_IBVB
Avian infectious bronchitis virus (strain Beaudette)
Replicase polyprotein 1ab

PDB Structure

PDB 3EJF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.
Piotrowski, Y., Hansen, G., Boomaars-van der Zanden, A.L., Snijder, E.J., Gorbalenya, A.E., Hilgenfeld, R.
Protein Sci.