CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.310 | TATA-Binding Protein |
|
3.30.310.130 | Ubiquitin-related |
Domain Context
CATH Clusters
| Superfamily | Ubiquitin-related |
| Functional Family | Sentrin-specific protease 7 |
Enzyme Information
| 3.4.22.68 |
Ulp1 peptidase.
based on mapping to UniProt Q9BQF6
Hydrolysis of the alpha-linked peptide bond in the sequence Gly- Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
-!- The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions. -!- Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. -!- Belongs to peptidase family C48.
|
UniProtKB Entries (1)
| Q9BQF6 |
SENP7_HUMAN
Homo sapiens
Sentrin-specific protease 7
|
PDB Structure
| PDB | 3EAY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7.
J.Biol.Chem.
|
