CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Tyrosine aminotransferase

Enzyme Information

2.6.1.5
Tyrosine transaminase.
based on mapping to UniProt P17735
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
-!- L-phenylalanine can act instead of L-tyrosine. -!- The mitochondrial enzyme may be identical with EC 2.6.1.1. -!- The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33. -!- The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.

UniProtKB Entries (1)

P17735
ATTY_HUMAN
Homo sapiens
Tyrosine aminotransferase

PDB Structure

PDB 3DYD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Tyrosine Aminotransferase
Karlberg, T., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nordlund, P., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wikstrom, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
To be Published