CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1820
Functional Family Protease II (Oligopeptidase B)

Enzyme Information

3.4.21.26
Prolyl oligopeptidase.
based on mapping to UniProt P48147
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P48147
PPCE_HUMAN
Homo sapiens
Prolyl endopeptidase

PDB Structure

PDB 3DDU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
Haffner, C.D., Diaz, C.J., Miller, A.B., Reid, R.A., Madauss, K.P., Hassell, A., Hanlon, M.H., Porter, D.J., Becherer, J.D., Carter, L.H.
Bioorg.Med.Chem.Lett.