CATH Domain 3dbeA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt Q4KMI8

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q4KMI8

Q4KMI8_DANRE

Danio rerio

Serine/threonine-protein kinase PLK

PDB Structure

PDB	3DBE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Fucini, R.V., Hanan, E.J., Romanowski, M.J., Elling, R.A., Lew, W., Barr, K.J., Zhu, J., Yoburn, J.C., Liu, Y., Fahr, B.T., Fan, J., Lu, Y., Pham, P., Choong, I.C., VanderPorten, E.C., Bui, M., Purkey, H.E., Evanchik, M.J., Yang, W. Bioorg.Med.Chem.Lett.