CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family Translation elongation factor LepA

Enzyme Information

3.6.5.n1
Elongation factor 4.
based on mapping to UniProt P60785
GTP + H(2)O = GDP + phosphate.
-!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner.

UniProtKB Entries (1)

P60785
LEPA_ECOLI
Escherichia coli K-12
Elongation factor 4

PDB Structure

PDB 3CB4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of LepA, the ribosomal back translocase.
Evans, R.N., Blaha, G., Bailey, S., Steitz, T.A.
Proc.Natl.Acad.Sci.Usa