CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1820
Functional Family Protein phosphatase methylesterase 1

Enzyme Information

3.1.1.89
Protein phosphatase methylesterase-1.
based on mapping to UniProt Q9Y570
[Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
-!- A key regulator of protein phosphatase 2A. -!- The methyl ester is formed by EC 2.1.1.233. -!- Occurs mainly in the nucleus.
3.1.1.-
Carboxylic ester hydrolases.
based on mapping to UniProt Q9Y570

UniProtKB Entries (1)

Q9Y570
PPME1_HUMAN
Homo sapiens
Protein phosphatase methylesterase 1

PDB Structure

PDB 3C5V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Xing, Y., Li, Z., Chen, Y., Stock, J.B., Jeffrey, P.D., Shi, Y.
Cell(Cambridge,Mass.)