CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family D-inositol 3-phosphate glycosyltransferase

Enzyme Information

2.4.1.250
D-inositol-3-phosphate glycosyltransferase.
based on mapping to UniProt Q8NTA6
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O- (2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.
-!- The enzyme, which belongs to the GT-B fold superfamily, catalyzes the first dedicated reaction in the biosynthesis of mycothiol. -!- The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate. -!- A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate. -!- Formerly EC 2.4.1.n3.

UniProtKB Entries (1)

Q8NTA6
MSHA_CORGL
Corynebacterium glutamicum ATCC 13032
D-inositol 3-phosphate glycosyltransferase

PDB Structure

PDB 3C48
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Enzymatic Analysis of MshA from Corynebacterium glutamicum: SUBSTRATE-ASSISTED CATALYSIS
Vetting, M.W., Frantom, P.A., Blanchard, J.S.
J.Biol.Chem.