CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1110 | Calcium-transporting ATPase, transmembrane domain |
|
1.20.1110.10 | Calcium-transporting ATPase, transmembrane domain |
Domain Context
CATH Clusters
| Superfamily | Calcium-transporting ATPase, transmembrane domain |
| Functional Family | Sodium/potassium-transporting ATPase alpha subunit |
Enzyme Information
| 3.6.3.9 |
Sodium/potassium-exchanging ATPase.
based on mapping to UniProt P05024
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37.
|
UniProtKB Entries (1)
| P05024 |
AT1A1_PIG
Sus scrofa
Sodium/potassium-transporting ATPase subunit alpha-1
|
PDB Structure
| PDB | 3B8E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the sodium-potassium pump.
Nature
|
