CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family ATP-dependent DNA helicase Hel308

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt O73946
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O73946
HELS_PYRFU
Pyrococcus furiosus DSM 3638
ATP-dependent DNA helicase Hel308

PDB Structure

PDB 2ZJ5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
Oyama, T., Oka, H., Mayanagi, K., Shirai, T., Matoba, K., Fujikane, R., Ishino, Y., Morikawa, K.
Bmc Struct.Biol.