CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.180 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 |
|
3.10.180.10 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
| Functional Family | Biphenyl-2,3-diol 1,2-dioxygenase |
Enzyme Information
| 1.13.11.39 |
Biphenyl-2,3-diol 1,2-dioxygenase.
based on mapping to UniProt P9WNW7
Biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate.
-!- This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyzes the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56. -!- The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently. -!- The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol. -!- The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2- dihydroxydibenzofuran and 1,2-dihydroxynaphthalene. -!- The enzyme is strongly inhibited by the substrate. -!- Not identical with EC 1.13.11.2.
|
| 1.13.11.- |
With incorporation of two atoms of oxygen.
based on mapping to UniProt P9WNW7
|
| 1.13.11.25 |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5- dioxygenase.
based on mapping to UniProt P9WNW7
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate.
-!- Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
|
UniProtKB Entries (1)
| P9WNW7 |
HSAC_MYCTU
Mycobacterium tuberculosis H37Rv
Iron-dependent extradiol dioxygenase
|
PDB Structure
| PDB | 2ZI8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
Plos Pathog.
|