CATH Classification

Domain Context

CATH Clusters

Superfamily Chloroperoxidase-like
Functional Family Aromatic peroxygenase

Enzyme Information
Unspecific peroxygenase.
based on mapping to UniProt B9W4V6
RH + H(2)O(2) = ROH + H(2)O.
-!- Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. -!- They catalyze the insertion of an oxygen atom from H(2)O(2) into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. -!- Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. -!- They have little or no activity toward chloride. -!- Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD(P)H) and the classic heme peroxidase cycle.

UniProtKB Entries (1)

Agrocybe aegerita
Aromatic peroxygenase

PDB Structure

External Links
Primary Citation
Structural Basis of Substrate Conversion in a New Aromatic Peroxygenase: P450 Functionality with Benefits
Piontek, K., Strittmatter, E., Ullrich, R., Grobe, G., Pecyna, M.J., Kluge, M., Scheibner, K., Hofrichter, M., Plattner, D.A.