CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Enzyme Information

2.7.1.60
N-acylmannosamine kinase.
based on mapping to UniProt Q9Y223
ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.
-!- Acts on the acetyl and glycolyl derivatives.
3.2.1.183
UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
based on mapping to UniProt Q9Y223
UDP-N-acetyl-alpha-D-glucosamine + H(2)O = N-acetyl-D-mannosamine + UDP.
-!- The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus. -!- It catalyzes the first step of sialic acid (N-acetylneuraminic acid) biosynthesis. -!- The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers. -!- The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60. -!- Cf. EC 5.1.3.14.

UniProtKB Entries (1)

Q9Y223
GLCNE_HUMAN
Homo sapiens
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

PDB Structure

PDB 2YHW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition
Martinez, J., Nguyen, L.D., Tauberger, E., Hinderlich, S., Reutter, W., Fan, H., Saenger, W., Moniot, S.
J.Biol.Chem.