CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family U8 snoRNA-decapping enzyme

Enzyme Information

3.6.1.64
Inosine diphosphate phosphatase.
based on mapping to UniProt Q96DE0
(1) IDP + H(2)O = IMP + phosphate. (2) dIDP + H(2)O = dIMP + phosphate.
-!- The human enzyme also hydrolyzes GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
3.6.1.62
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
based on mapping to UniProt Q96DE0
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].
-!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover. -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG). -!- The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+). -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96DE0
NUD16_HUMAN
Homo sapiens
U8 snoRNA-decapping enzyme

PDB Structure

PDB 2XSQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for the Specificity of Human Nudt16 and its Regulation by Inosine Monophosphate.
Tresaugues, L., Lundback, T., Welin, M., Flodin, S., Nyman, T., Silvander, C., Graslund, S., Nordlund, P.
Plos One