CATH Classification

Domain Context

CATH Clusters

Superfamily Aromatic amino acid hydroxylase
Functional Family Aromatic amino acid hydroxylase 1

Enzyme Information

1.14.16.2
Tyrosine 3-monooxygenase.
based on mapping to UniProt P07101
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
-!- Activated by phosphorylation, catalyzed by EC 2.7.11.27. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.

UniProtKB Entries (1)

P07101
TY3H_HUMAN
Homo sapiens
Tyrosine 3-monooxygenase

PDB Structure

PDB 2XSN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
To be Published