CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.268 | Topoisomerase; domain 3 | |
1.10.268.10 | Topoisomerase, domain 3 |
Domain Context
CATH Clusters
Superfamily | Topoisomerase, domain 3 |
Functional Family | DNA gyrase subunit A |
Enzyme Information
5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q99XG5
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
UniProtKB Entries (1)
Q99XG5 |
GYRA_STAAN
Staphylococcus aureus subsp. aureus N315
DNA gyrase subunit A
|
PDB Structure
PDB | 2XCR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Nature
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