CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Orotate phosphoribosyltransferase (PyrE)

Enzyme Information

2.4.2.10
Orotate phosphoribosyltransferase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
4.1.1.23
Orotidine-5'-phosphate decarboxylase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate = UMP + CO(2).
-!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.

UniProtKB Entries (1)

P11172
UMPS_HUMAN
Homo sapiens
Uridine 5'-monophosphate synthase

PDB Structure

PDB 2WNS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp)
Moche, M., Roos, A., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotyenova, T., Kotzch, A., Nielsen, T.K., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Vandenberg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P.
To be Published