CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Probable histone-lysine N-methyltransferase set-2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q03164
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q03164
KMT2A_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase 2A

PDB Structure

PDB 2W5Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Southall, S.M., Wong, P.S., Odho, Z., Roe, S.M., Wilson, J.R.
Mol.Cell