CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Probable tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt Q58530
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q58530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Methanocaldococcus jannaschii DSM 2661
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein

PDB Structure

External Links
Primary Citation
Structure of the Archaeal Kae1/Bud32 Fusion Protein Mj1130: A Model for the Eukaryotic Ekc/Keops Subcomplex
Hecker, A., Lopreiato, R., Graille, M., Collinet, B., Forterre, P., Libri, D., Van Tilbeurgh, H.
Embo J.