CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family A disintegrin and metalloproteinase with

Enzyme Information
ADAMTS-4 endopeptidase.
based on mapping to UniProt O75173
Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala- Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
-!- Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

Homo sapiens
A disintegrin and metalloproteinase with thrombospondin motifs 4

PDB Structure

External Links
Organism Cricetulus
Primary Citation
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Mosyak, L., Georgiadis, K., Shane, T., Svenson, K., Hebert, T., McDonagh, T., Mackie, S., Olland, S., Lin, L., Zhong, X., Kriz, R., Reifenberg, E.L., Collins-Racie, L.A., Corcoran, C., Freeman, B., Zollner, R., Marvell, T., Vera, M., Sum, P.E., Lavallie, E.R., Stahl, M., Somers, W.
Protein Sci.