CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.920 | Pyruvate-ferredoxin Oxidoreductase; domain 3 |
|
3.40.920.10 | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III |
Domain Context
CATH Clusters
| Superfamily | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III |
| Functional Family | Pyruvate oxidoreductase gamma subunit |
Enzyme Information
| 1.2.7.1 |
Pyruvate synthase.
based on mapping to UniProt O05650
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
-!- The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate. -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. -!- For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
|
UniProtKB Entries (1)
| O05650 |
PORC_THEMA
Thermotoga maritima MSB8
Pyruvate synthase subunit PorC
|
PDB Structure
| PDB | 2RAA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of pyruvate oxidoreductase subunit PORC (EC 1.2.7.1) (TM0015) from Thermotoga maritima at 2.12 A resolution
To be published
|