CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Beta-galactoside-specific lectin 4

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt Q9M6E9
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

Q9M6E9
AGGL_ABRPR
Abrus precatorius
Agglutinin-1

PDB Structure

PDB 2Q3N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Function Analysis and Insights into the Reduced Toxicity of Abrus precatorius Agglutinin I in Relation to Abrin.
Bagaria, A., Surendranath, K., Ramagopal, U.A., Ramakumar, S., Karande, A.A.
J.Biol.Chem.