CATH Domain 2pw6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.830	Protocatechuate 4,5-dioxygenase; Chain B
	3.40.830.10	LigB-like

Domain Context

CATH Clusters

Superfamily	LigB-like
Functional Family	4,5-DOPA dioxygenase extradiol 1

Enzyme Information

1.13.-.-	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O(2). based on mapping to UniProt P24197
1.13.11.29	Stizolobate synthase. based on mapping to UniProt P24197 L-dopa + O(2) = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. -!- The intermediate product undergoes ring closure and oxidation, with NAD(P)(+) as acceptor, to stizolobic acid.

UniProtKB Entries (1)

YGID_ECOLI

Escherichia coli K-12

4,5-DOPA dioxygenase extradiol

PDB Structure

PDB	2PW6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of uncharacterized protein JW3007 from Escherichia coli K12. Newton, M.G., Takagi, Y., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokayama, S., Li, Y., Chen, L., Zhu, J., Ruble, J., Liu, Z.J., Rose, J.P., Wang, B.-C. To be Published