CATH Domain 2pv7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Chorismate mutase I / Cyclohexadienyl dehydrogenase

Enzyme Information

5.4.99.5	Chorismate mutase. based on mapping to UniProt P43902 Chorismate = prephenate.
1.3.1.12	Prephenate dehydrogenase. based on mapping to UniProt P43902 Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH. -!- This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate.

UniProtKB Entries (1)

TYRA_HAEIN

Haemophilus influenzae Rd KW20

T-protein

PDB Structure

PDB	2PV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes. Chiu, H.J., Abdubek, P., Astakhova, T., Axelrod, H.L., Carlton, D., Clayton, T., Das, D., Deller, M.C., Duan, L., Feuerhelm, J., Grant, J.C., Grzechnik, A., Han, G.W., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Kozbial, P., Krishna, S.S., Kumar, A., Marciano, D., McMullan, D., Miller, M.D., Morse, A.T., Nigoghossian, E., Okach, L., Reyes, R., Tien, H.J., Trame, C.B., van den Bedem, H., Weekes, D., Xu, Q., Hodgson, K.O., Wooley, J., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. Acta Crystallogr.,Sect.F