1 keywords

CATH Domain 2pv7A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.720 NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Chorismate mutase I / Cyclohexadienyl dehydrogenase

Enzyme Information

5.4.99.5
Chorismate mutase.
based on mapping to UniProt P43902
Chorismate = prephenate.
1.3.1.12
Prephenate dehydrogenase.
based on mapping to UniProt P43902
Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH.
-!- This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate.

UniProtKB Entries (1)

P43902
TYRA_HAEIN
Haemophilus influenzae Rd KW20
T-protein

PDB Structure

PDB 2PV7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.
Chiu, H.J., Abdubek, P., Astakhova, T., Axelrod, H.L., Carlton, D., Clayton, T., Das, D., Deller, M.C., Duan, L., Feuerhelm, J., Grant, J.C., Grzechnik, A., Han, G.W., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Kozbial, P., Krishna, S.S., Kumar, A., Marciano, D., McMullan, D., Miller, M.D., Morse, A.T., Nigoghossian, E., Okach, L., Reyes, R., Tien, H.J., Trame, C.B., van den Bedem, H., Weekes, D., Xu, Q., Hodgson, K.O., Wooley, J., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A.
Acta Crystallogr.,Sect.F