CATH Domain 2pk3A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	GDP-mannose 4,6-dehydratase

Enzyme Information

1.1.1.281

GDP-4-dehydro-6-deoxy-D-mannose reductase.

based on mapping to UniProt Q6T1X6

GDP-alpha-D-rhamnose + NAD(P)(+) = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H.

-!- Differs from EC 1.1.1.187 in that the only product formed is GDP- alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose). -!- D-rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.

UniProtKB Entries (1)

Q6T1X6

RMD_ANETH

Aneurinibacillus thermoaerophilus

GDP-6-deoxy-D-mannose reductase

PDB Structure

PDB	2PK3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway. King, J.D., Poon, K.K., Webb, N.A., Anderson, E.M., McNally, D.J., Brisson, J.R., Messner, P., Garavito, R.M., Lam, J.S. Febs J.