CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Hydroxymethylglutaryl-CoA synthase, expressed (Eurofung) |
Enzyme Information
| 2.3.3.10 |
Hydroxymethylglutaryl-CoA synthase.
based on mapping to UniProt Q01581
Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
-!- Formerly EC 4.1.3.5.
|
UniProtKB Entries (1)
| Q01581 |
HMCS1_HUMAN
Homo sapiens
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
|
PDB Structure
| PDB | 2P8U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol.
|