1 keywords

CATH Domain 2p4eA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.200 Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-
Serine endopeptidases.
based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

Q8NBP7
PCSK9_HUMAN
Homo sapiens
Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB 2P4E
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Cunningham, D., Danley, D.E., Geoghegan, K.F., Griffor, M.C., Hawkins, J.L., Subashi, T.A., Varghese, A.H., Ammirati, M.J., Culp, J.S., Hoth, L.R., Mansour, M.N., McGrath, K.M., Seddon, A.P., Shenolikar, S., Stutzman-Engwall, K.J., Warren, L.C., Xia, D., Qiu, X.
Nat.Struct.Mol.Biol.