CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.930 | Mannitol-specific EII; Chain A | |
3.40.930.10 | Mannitol-specific EII; Chain A |
Domain Context
CATH Clusters
Superfamily | Mannitol-specific EII; Chain A |
Functional Family | PTS system, IIA component |
Enzyme Information
2.7.1.197 |
Protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase.
based on mapping to UniProt P69824
[Protein]-N(pi)-phospho-L-histidine + D-mannitol(Side 1) = [protein]-L- histidine + D-mannitol 1-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate--protein phosphotransferase). -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.
|
2.7.1.69 |
Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208.
based on mapping to UniProt P69824
|
2.7.1.- |
Phosphotransferases with an alcohol group as acceptor.
based on mapping to UniProt P69824
|
UniProtKB Entries (1)
P69824 |
PTMA_ECOLI
Escherichia coli K-12
Mannitol-specific cryptic phosphotransferase enzyme IIA component
|
PDB Structure
PDB | 2OQ3 |
External Links | |
Method | SOLUTION NMR |
Organism | Escherichia |
Primary Citation |
Solution structure of the cryptic mannitol-specific phosphotransferase enzyme IIA CmtB from Escherichia coli
Biochem.Biophys.Res.Commun.
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