CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Non-specific protein-tyrosine kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43403
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43403
ZAP70_HUMAN
Homo sapiens
Tyrosine-protein kinase ZAP-70

PDB Structure

PDB 2OQ1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular basis for the interaction of ZAP-70 with the T-cell receptor
Hatada, M.H., Lu, X., Laird, E.R., Green, J., Morgenstern, J.P., Lou, M., Marr, C., Phillips, T.B., Ram, M.K., Theriault, K.
Nature