CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt O00444
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O00444
PLK4_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK4

PDB Structure

PDB 2N19
External Links
Method SOLUTION NMR
Organism
Primary Citation
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Arquint, C., Gabryjonczyk, A.M., Imseng, S., Bohm, R., Sauer, E., Hiller, S., Nigg, E.A., Maier, T.
Elife