CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.110 | 4 Propeller |
|
2.110.10 | Hemopexin |
|
2.110.10.10 | Hemopexin-like domain |
Domain Context
CATH Clusters
| Superfamily | Hemopexin-like domain |
| Functional Family | Membrane-inserted matrix metallopeptidase 14 |
Enzyme Information
| 3.4.24.80 |
Membrane-type matrix metalloproteinase-1.
based on mapping to UniProt P50281
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.
|
UniProtKB Entries (1)
| P50281 |
MMP14_HUMAN
Homo sapiens
Matrix metalloproteinase-14
|
PDB Structure
| PDB | 2MQS |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Transient collagen triple helix binding to a key metalloproteinase in invasion and development.
Structure
|