CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (Central domain)
Functional Family Adenylosuccinate lyase isoform B

Enzyme Information

4.3.2.2
Adenylosuccinate lyase.
based on mapping to UniProt P30566
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

P30566
PUR8_HUMAN
Homo sapiens
Adenylosuccinate lyase

PDB Structure

PDB 2J91
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Adenylosuccinate Lyase
Stenmark, P., Moche, M., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Johansson, I., Karlberg, T., Kosinska, U., Kotenyova, T., Magnusdottir, A., Nilsson, M.E., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Uppsten, M., Thorsell, A.G., Van Den Berg, S., Wallden, K., Weigelt, J., Nordlund, P.
To be Published