CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Putative NADP-dependent oxidoreductase P1

Enzyme Information

1.3.1.74
2-alkenal reductase (NAD(P)(+)).
based on mapping to UniProt Q39172
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
-!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).

UniProtKB Entries (1)

Q39172
P1_ARATH
Arabidopsis thaliana
NADP-dependent alkenal double bond reductase P1

PDB Structure

PDB 2J3H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic and Structural Studies of Apoform, Binary, and Ternary Complexes of the Arabidopsis Alkenal Double Bond Reductase at5G16970.
Youn, B., Kim, S.J., Moinuddin, S.G., Lee, C., Bedgar, D.L., Harper, A.R., Davin, L.B., Lewis, N.G., Kang, C.
J.Biol.Chem.