CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Homolog to ornithine cyclodeaminase

Enzyme Information

1.5.1.25
Thiomorpholine-carboxylate dehydrogenase.
based on mapping to UniProt Q14894
Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3- carboxylate + NAD(P)H.
-!- The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. -!- In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, more slowly.

UniProtKB Entries (1)

Q14894
CRYM_HUMAN
Homo sapiens
Ketimine reductase mu-crystallin

PDB Structure

PDB 2I99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human {micro}-crystallin complexed with NADPH
Cheng, Z., Sun, L., He, J., Gong, W.
Protein Sci.