CATH Classification

Domain Context

CATH Clusters

Superfamily Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3
Functional Family ATP synthase subunit beta

Enzyme Information

3.6.3.14
H(+)-transporting two-sector ATPase.
based on mapping to UniProt P00830
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
-!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)). -!- The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. -!- All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. -!- Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. -!- This movement is driven by the H(+) electrochemical potential gradient. -!- The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP. -!- Formerly EC 3.6.1.34.

UniProtKB Entries (1)

Q12165
ATPD_YEAST
Saccharomyces cerevisiae S288C
ATP synthase subunit delta, mitochondrial

PDB Structure

PDB 2HLD
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Novel features of the rotary catalytic mechanism revealed in the structure of yeast F(1) ATPase.
Kabaleeswaran, V., Puri, N., Walker, J.E., Leslie, A.G., Mueller, D.M.
Embo J.