CATH Classification

Domain Context

CATH Clusters

Superfamily DNA helicase RuvA subunit, C-terminal domain
Functional Family Holliday junction DNA helicase RuvA

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P9WGW3
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P9WGW3
RUVA_MYCTU
Mycobacterium tuberculosis H37Rv
Holliday junction ATP-dependent DNA helicase RuvA

PDB Structure

PDB 2H5X
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination.
Prabu, J.R., Thamotharan, S., Khanduja, J.S., Alipio, E.Z., Kim, C.Y., Waldo, G.S., Terwilliger, T.C., Segelke, B., Lekin, T., Toppani, D., Hung, L.W., Yu, M., Bursey, E., Muniyappa, K., Chandra, N.R., Vijayan, M.
ACTA CRYSTALLOGR.,SECT.F