CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 15-hydroxyprostaglandin dehydrogenase [NAD+]-like protein

Enzyme Information

1.1.1.141
15-hydroxyprostaglandin dehydrogenase (NAD(+)).
based on mapping to UniProt P15428
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.
-!- Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197).

UniProtKB Entries (1)

P15428
PGDH_HUMAN
Homo sapiens
15-hydroxyprostaglandin dehydrogenase [NAD(+)]

PDB Structure

PDB 2GDZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Niesen, F.H., Schultz, L., Jadhav, A., Bhatia, C., Guo, K., Maloney, D.J., Pilka, E.S., Wang, M., Oppermann, U., Heightman, T.D., Simeonov, A.
Plos One