CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Isoflavone reductase |
Enzyme Information
| 1.3.1.45 |
2'-hydroxyisoflavone reductase.
based on mapping to UniProt P52575
Vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH.
-!- In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. -!- Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
|
UniProtKB Entries (1)
| P52575 |
IFR_MEDSA
Medicago sativa
Isoflavone reductase
|
PDB Structure
| PDB | 2GAS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Isoflavone Reductase from Alfalfa (Medicago sativa L.)
J.Mol.Biol.
|