CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.30 | Glutaredoxin |
|
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
| Superfamily | Glutaredoxin |
| Functional Family | NADH dehydrogenase subunit E |
Enzyme Information
| 1.6.5.3 |
NADH:ubiquinone reductase (H(+)-translocating).
based on mapping to UniProt Q56221
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
|
| 1.6.5.11 |
NADH dehydrogenase (quinone).
based on mapping to UniProt Q56221
NADH + a quinone = NAD(+) + a quinol.
-!- Menaquinone or other quinones can act as acceptor. -!- Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. -!- Formerly EC 1.6.99.5.
|
UniProtKB Entries (1)
| Q56222 |
NQO1_THET8
Thermus thermophilus HB8
NADH-quinone oxidoreductase subunit 1
|
PDB Structure
| PDB | 2FUG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
Science
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