CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Phosphoinositide phospholipase C

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P24135
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P24135
PLCG2_RAT
Rattus norvegicus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

PDB Structure

PDB 2EOB
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the second SH2 domain from rat PLC gamma-2
Sano, R., Hayashi, F., Nagashima, T., Yoshida, M., Yokoyama, S.
To be Published