CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Proto-oncogene tyrosine-protein kinase src

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q922K9
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q922K9
FRK_MOUSE
Mus musculus
Tyrosine-protein kinase FRK

PDB Structure

PDB 2DLY
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the SH2 domain of murine Fyn-related kinase
Endo, H., Hayashi, F., Yoshida, M., Yokoyama, S.
To be Published