CATH Classification

Domain Context

CATH Clusters

Superfamily WGR domain
Functional Family Poly [ADP-ribose] polymerase 1

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt P09874
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

P09874
PARP1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 1

PDB Structure

PDB 2CR9
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of WGR domain of poly(ADP-ribose) polymerase-1
Nagashima, T., Hayashi, F., Yokoyama, S.
To be published