CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.465 | Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 |
|
3.30.465.10 |
Domain Context
CATH Clusters
| Superfamily | 3.30.465.10 |
| Functional Family | FAD binding domain protein |
Enzyme Information
| 1.5.3.6 |
(R)-6-hydroxynicotine oxidase.
based on mapping to UniProt Q8GAG1
(R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyridin-3-yl)-4- (methylamino)butan-1-one + H(2)O(2).
-!- The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)- nicotine. -!- The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the (S)-isomer (cf. EC 1.5.3.5).
|
UniProtKB Entries (1)
| Q8GAG1 |
Q8GAG1_PAENI
Paenarthrobacter nicotinovorans
6-hydroxy-D-nicotine oxidase
|
PDB Structure
| PDB | 2BVF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of 6-Hydroxy-D-Nicotine Oxidase from Arthrobacter Nicotinovorans.
J.Mol.Biol.
|
