CATH Domain 2bddA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.470	Ribosomal Protein L22; Chain A
	3.90.470.20	4'-phosphopantetheinyl transferase domain

Domain Context

CATH Clusters

Superfamily	4'-phosphopantetheinyl transferase domain
Functional Family	Mitochondrial holo-[acyl-carrier-protein] synthase

Enzyme Information

2.7.8.7

Holo-[acyl-carrier-protein] synthase.

based on mapping to UniProt Q7RB63

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

-!- All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. -!- The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain. -!- The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty acid synthase and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier- proteins from prokaryotes. -!- Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14.

UniProtKB Entries (1)

Q7RB63

Q7RB63_PLAYO

Plasmodium yoelii yoelii

Uncharacterized protein

PDB Structure

PDB	2BDD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Vedadi, M., Lew, J., Artz, J., Amani, M., Zhao, Y., Dong, A., Wasney, G.A., Gao, M., Hills, T., Brokx, S., Qiu, W., Sharma, S., Diassiti, A., Alam, Z., Melone, M., Mulichak, A., Wernimont, A., Bray, J., Loppnau, P., Plotnikova, O., Newberry, K., Sundararajan, E., Houston, S., Walker, J., Tempel, W., Bochkarev, A., Kozieradzki, I., Edwards, A., Arrowsmith, C., Roos, D., Kain, K., Hui, R. Mol.Biochem.Parasitol.