CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.360 | Flavodoxin domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.360 |
| Functional Family | NADPH quinone reductase MdaB |
Enzyme Information
| 1.6.5.2 |
NAD(P)H dehydrogenase (quinone).
based on mapping to UniProt P0AEY5
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.
|
| 1.6.99.6 |
Transferred entry: 1.6.5.10.
based on mapping to UniProt P0AEY5
|
| 1.6.5.10 |
NADPH dehydrogenase (quinone).
based on mapping to UniProt P0AEY5
NADPH + a quinone = NADP(+) + a quinol.
-!- The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors. -!- Menaquinone can act as acceptor. -!- The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol. -!- Formerly EC 1.6.99.6.
|
UniProtKB Entries (1)
| P0AEY5 |
MDAB_ECOLI
Escherichia coli K-12
Modulator of drug activity B
|
PDB Structure
| PDB | 2B3D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Modulator of drug activity B from Escherichia coli: crystal structure of a prokaryotic homologue of DT-diaphorase.
J.Mol.Biol.
|