CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Phenylethanolamine N-methyltransferase

Enzyme Information
Amine N-methyltransferase.
based on mapping to UniProt O95050
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
-!- An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics. -!- Formerly EC
Thioether S-methyltransferase.
based on mapping to UniProt O95050
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.
-!- Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.

UniProtKB Entries (1)

Homo sapiens
Indolethylamine N-methyltransferase

PDB Structure

PDB 2A14
External Links
Organism Escherichia
Primary Citation
The Crystal Structure of Human Indolethylamine N-methyltransferase in complex with SAH.
Wu, H., Dong, A., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N.
To be Published