CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Phenylethanolamine N-methyltransferase |
Enzyme Information
| 2.1.1.49 |
Amine N-methyltransferase.
based on mapping to UniProt O95050
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
-!- An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics. -!- Formerly EC 2.1.1.81.
|
| 2.1.1.96 |
Thioether S-methyltransferase.
based on mapping to UniProt O95050
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.
-!- Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
|
UniProtKB Entries (1)
| O95050 |
INMT_HUMAN
Homo sapiens
Indolethylamine N-methyltransferase
|
PDB Structure
| PDB | 2A14 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Crystal Structure of Human Indolethylamine
N-methyltransferase in complex with SAH.
To be Published
|