CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family Sulfate adenylyltransferase subunit 1

Enzyme Information

2.7.7.4
Sulfate adenylyltransferase.
based on mapping to UniProt Q87WW1
ATP + sulfate = diphosphate + adenylyl sulfate.
-!- The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP. -!- This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.

UniProtKB Entries (1)

Q87WW1
Q87WW1_PSESM
[Pseudomonas syringae] pv. tomato str. DC3000
Sulfate adenylyltransferase subunit 1

PDB Structure

PDB 1ZUN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular basis for g protein control of the prokaryotic ATP sulfurylase.
Mougous, J.D., Lee, D.H., Hubbard, S.C., Schelle, M.W., Vocadlo, D.J., Berger, J.M., Bertozzi, C.R.
Mol.Cell